Nancy Guthrie, 84, has been missing for nearly three weeks and investigators are still piecing together sparse forensic leads, surveillance footage and a puzzling mix of public silence and targeted investigative moves.

The search began when Nancy Guthrie was reported missing on February 1 and has produced frustratingly little clarity. Surveillance captured a masked person near her Pima County home, described as about 5 feet 9 inches to 5 feet 10 inches tall with an average build, but that figure remains unidentified. Investigators say they believe she was taken during the late night or early morning hours, and the case has drawn national attention.

DNA recovered from gloves found near Guthrie’s Pima County home was submitted to a lab in Florida, uploaded to CODIS, the FBI’s national DNA database, and came back with nothing. No match. No suspect. No closer to bringing her home.

Officials confirmed the glove DNA returned no match in CODIS, and they added that more biological material from the residence is still being examined. The fact that the gloves produced a negative CODIS hit simply means the profile was not already in the system, not that the evidence lacks value. Lab work can still connect pieces together or rule people in or out as results come back.

Two ransom deadlines have passed without resolution, and early in the case ransom notes were sent to media outlets. TMZ also received four separate emails from someone offering information in exchange for money, though the sender’s credibility and links to the disappearance remain unknown. Investigators have not publicly confirmed any direct contact between the suspected captors and the Guthrie family.

The probe seems to be wider than the public updates suggest. FBI agents reportedly visited gun stores in the area with a list of about 40 names and photos, asking whether anyone on that list had recently been in the shops or bought a weapon. That kind of targeted canvass points to a specific pool of people investigators want to check rather than a random sweep.

Investigators also announced that family members, including spouses of relatives, have been cleared as suspects. Law enforcement typically works from the inside out in abduction cases, so clearing the household is a common early step and shifts focus outward. That development underscores a troubling possibility: the person or people responsible may be a stranger or only loosely connected to the family, which complicates the search and makes predicting motives harder.

One grim, practical detail is now part of the effort: officials are trying to pick up a signal from Guthrie’s pacemaker. At 84 years old, she relies on that device to keep her heart functioning, and detectives are using equipment to scan for its electronic pulse as another way to try to locate her. Using a pacemaker signal underscores both the urgency and the scarcity of other leads to follow.

Forensic work continues beyond the glove DNA. Other samples from the scene remain in analysis, and while CODIS can only return a hit if a profile already exists in the national database, a match in other tests could still connect a person to the scene. DNA processing nationwide can take time, and investigators often combine genetic results with phone records, surveillance, and witness accounts when they can.

The FBI has offered up to $100,000 for information that leads to Guthrie’s recovery or to the arrest and conviction of anyone involved, and local authorities continue active inquiries. Anyone with tips is asked to call 1-800-CALL-FBI or the Pima County Sheriff’s Department nonemergency line at 520-351-4900. Those lines remain the official routes for credible leads.

The case remains active and frustratingly opaque to the public, with key physical evidence failing to identify a suspect so far and investigators chasing technological and human traces. The search includes methodical canvassing, forensic testing, and electronic detection efforts as teams try to turn thin threads into a location or a name. The clock keeps pressing on a woman who needs medical care and the investigators trying to bring her home.